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Article

A MIG-15/JNK-1 MAP kinase cascade opposes RPM-1 signaling in synapse formation and learning.

PLoS genetics - 1 Dec 2017

Crawley Oliver, Giles Andrew C, Desbois Muriel, Kashyap Sudhanva, Birnbaum Rayna, Grill Brock

Abstract excerpt

The Pam/Highwire/RPM-1 (PHR) proteins are conserved intracellular signaling hubs that regulate synapse formation and axon termination. The C. elegans PHR protein, called RPM-1, acts as a ubiquitin ligase to inhibit the DLK-1 and MLK-1 MAP kinase pathways. We have identified several kinases that are likely to form a new MAP kinase pathway that suppresses synapse formation defects, but not axon termination defects,...

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Identifiers

PMID: 29228003
DOI: 10.1371/journal.pgen.1007095
PMCID: PMC5754208

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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