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Article

Histone demethylase JMJD2D activates HIF1 signaling pathway via multiple mechanisms to promote colorectal cancer glycolysis and progression.

Oncogene - 1 Nov 2020

Peng Kesong, Zhuo Minghui, Li Ming, Chen Qiang, Mo Pingli, Yu Chundong

Abstract excerpt

Hypoxia-inducible factor 1 (HIF1) signaling pathway plays a key role in cancer progression by enhancing glycolysis through activating the transcription of glycolytic genes. JMJD2D, a histone demethylase that specifically demethylates H3K9me2/3, can promote colorectal cancer (CRC) progression. However, it is unknown whether JMJD2D could promote CRC progression by enhancing glycolysis through activating HIF1...

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PMID: 32989255
DOI: 10.1038/s41388-020-01483-w

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