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Article

CYP2D6 basic genotyping as a potential tool to improve the antiemetic efficacy of ondansetron in prophylaxis of postoperative nausea and vomiting.

Advances in clinical and experimental medicine : official organ Wroclaw Medical University - 1 Nov 2018

Niewiński Przemysław A, Wojciechowski Robert, Śliwiński Marek, Hurkacz Magdalena E, Głowacka Krystyna, Orzechowska-Juzwenko Krystyna, Wiela-Hojeńska Anna K

Abstract excerpt

BACKGROUND: Postoperative nausea and vomiting (PONV) is a common complication after anesthesia and surgery. Ondansetron is one of the most widely used drugs in the prophylaxis of PONV and is extensively metabolized in humans. In vitro metabolism studies have shown that ondansetron is a substrate for human hepatic cytochrome P450 enzymes. The cytochrome P450 (human hepatic cytochrome [CYP]) 2D6 inhibitor quinidine...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 30058787
DOI: 10.17219/acem/69451

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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