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Article

Impact of CYP2D6 Metabolizer Status on Ondansetron Efficacy in Early Pregnancy Induced Nausea and Vomiting: A Case Control Study.

Clinical and translational science - 1 Mar 2026

Liu Michelle, Shuey Megan M, Holley Sabrina E, Fountain Darlene F, Jaworski James, Griffin Carol, Kim Jeewoo, Stec Melissa, Sunthankar Sudeep D, Ong Henry H, Gangireddy Srushti, Wei Wei-Qi, Gaedigk Andrea, Velez Edwards Digna R, Kawai Vivian K

Abstract excerpt

Real-world data investigating CYP2D6 on the efficacy of ondansetron for nausea and vomiting in pregnancy (NVP) is lacking. Evidence shows CYP2D6 ultrarapid metabolizers are at risk of ondansetron nonresponse due to increased metabolism. We conducted a retrospective cohort study of early pregnant patients on ondansetron for NVP. Genotype data for 11 CYP2D6 variants and copy number variations were translated into...

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Identifiers

PMID: 41820792
DOI: 10.1111/cts.70523
PMCID: PMC13093447

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