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Article

Prevention of postoperative nausea and vomiting with granisetron and dolasetron in relation to CYP2D6 genotype.

Anesthesia and analgesia - 1 Apr 2006

Janicki Piotr K, Schuler H Gregg, Jarzembowski Tomasz M, Rossi Malina

Abstract excerpt

We investigated the efficacy of granisetron and dolasetron in preventing postoperative nausea and vomiting. Because the metabolism of the various antiemetic 5-hydroxytryptamine type 3 (5-HT3) antagonists involves different isoforms of the hepatic cytochrome P450 system, we examined the relationship between the clinical efficacy of these drugs and polymorphic cytochrome P450 2D6 (CYP2D6) genotype. This...

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PMID: 16551910
DOI: 10.1213/01.ane.0000200364.55798.3f

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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