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Article

CYP2D6- and CYP3A-dependent enantioselective plasma concentrations of ondansetron in postanesthesia care.

Anesthesia and analgesia - 1 Jul 2011

Stamer Ulrike M, Lee Eun-Hae, Rauers Neele I, Zhang Lan, Kleine-Brueggeney Maren, Fimmers Rolf, Stuber Frank, Musshoff Frank

Abstract excerpt

BACKGROUND: An influence of polymorphic cytochromes P450 (CYP) 2D6 genetic variants on antiemetic efficacy of ondansetron has been suggested. However, the role of CYP3A in ondansetron metabolism and efficacy has been unclear. In this study, we evaluated the hypothesis that genotype-dependent CYP2D6 and CYP3A activity selectively influences plasma concentrations of ondansetron enantiomers. Additionally, the...

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Source

Identifiers

PMID: 21596874
DOI: 10.1213/ANE.0b013e31821d01bc

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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