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Article

Serotonin uptake is required for Rac1 activation in Kras-induced acinar-to-ductal metaplasia in the pancreas.

The Journal of pathology - 1 Nov 2018

Saponara Enrica, Visentin Michele, Baschieri Francesco, Seleznik Gitta, Martinelli Paola, Esposito Irene, Buschmann Johanna, Chen Rong, Parrotta Rossella, Borgeaud Nathalie, Bombardo Marta, Malagola Ermanno, Caflisch Amedeo, Farhan Hesso, Graf Rolf, Sonda Sabrina

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC), which is the primary cause of pancreatic cancer mortality, is poorly responsive to currently available interventions. Identifying new targets that drive PDAC formation and progression is critical for developing alternative therapeutic strategies to treat this lethal malignancy. Using genetic and pharmacological approaches, we investigated in vivo and in vitro whether...

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Share to Carcinoma, Pancreatic Ductal
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 30058725
DOI: 10.1002/path.5147

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Serotonin uptake is required for Rac1 activation in Kras-induced acinar-to-ductal metaplasia in the pancreas.PMID 30058725Read ↗

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