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Article

Cilia loss sensitizes cells to transformation by activating the mevalonate pathway

13 Dec 2017

Abstract excerpt

Although cilia loss and cell transformation are frequently observed in the early stage of tumorigenesis, the roles of cilia in cell transformation are unknown. In this study, disrupted ciliogenesis was observed in cancer cells and pancreatic cancer tissues, which facilitated oncogene-induced transformation of normal pancreatic cells (HPDE6C7) and NIH3T3 cells through activating the mevalonate (MVA) pathway....

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PMID: 29237705
DOI: 10.1084/jem.20170399

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