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PsychENCODE at 10: From genomic maps to mechanistic insights in mental illness.

Neuron - 17 Dec 2025

Roussos Panos, Vaccarino Flora M, Weng Zhiping, Sestan Nenad, Gerstein Mark, Geschwind Daniel H

Abstract excerpt

Over the past decade, the PsychENCODE Consortium has transformed psychiatric genomics-from static maps of genetic risk to dynamic, cell-resolved models of the human brain-linking DNA sequence to neural circuitry and behavior and laying the foundation for precision approaches to mental illness.

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PMID: 41412064
DOI: 10.1016/j.neuron.2025.11.027

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