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Article

Nitric Oxide Activates β-Cell Glucokinase by Promoting Formation of the "Glucose-Activated" State.

Biochemistry - 28 Aug 2018

Seckinger Kendra M, Rao Vishnu P, Snell Nicole E, Mancini Allison E, Markwardt Michele L, Rizzo M A

Abstract excerpt

The release of insulin from the pancreas is tightly controlled by glucokinase (GCK) activity that couples β-cell metabolism to changes in blood sugar. Despite having only a single glucose-binding site, GCK displays positive glucose cooperativity. Ex vivo structural studies have identified several potential protein conformations with varying levels of enzymatic activity, yet it is unclear how living cells regulate...

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Identifiers

PMID: 30053375
DOI: 10.1021/acs.biochem.8b00333
PMCID: PMC6338087

Genes

GCK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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