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Article

Glucagon-like peptide 1 stimulates post-translational activation of glucokinase in pancreatic beta cells.

The Journal of biological chemistry - 13 May 2011

Ding Shi-Ying, Nkobena Andongfac, Kraft Catherine A, Markwardt Michele L, Rizzo Megan A

Abstract excerpt

Glucagon-like peptide 1 (GLP-1) potentiates glucose-stimulated insulin secretion from pancreatic β cells, yet does not directly stimulate secretion. The mechanisms underlying this phenomenon are incompletely understood. Here, we report that GLP-1 augments glucose-dependent rises in NAD(P)H autofluorescence in both βTC3 insulinoma cells and islets in a manner consistent with post-translational activation of...

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Identifiers

PMID: 21454584
DOI: 10.1074/jbc.M110.192799
PMCID: PMC3089519

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GCK

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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