Significance of mutations in the region coding for NS3/4 protease in patients infected with HCV genotype 1b.

doi:10.17219/acem/75511

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Article

Significance of mutations in the region coding for NS3/4 protease in patients infected with HCV genotype 1b.

Advances in clinical and experimental medicine : official organ Wroclaw Medical University - 1 Nov 2018

Łapiński Tadeusz W, Rogalska-Płońska Magdalena, Kowalczuk Oksana, Kiśluk Joanna, Zurnowska Joanna, Nikliński Jacek, Flisiak Robert

Abstract excerpt

BACKGROUND: Fast hepatitis C virus (HCV) replication is one of the reasons for frequent changes in viral genome. OBJECTIVES: The objective of this study was to evaluate the frequency and type of mutation in NS3/4 protease in patients with HCV genotype 1b and to determine the effect of the mutation on viral load, fibrosis stage, alanine aminotransferase (ALT) activity, and alpha-fetoprotein (AFP) level. MATERIAL...

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PMID: 30048050
DOI: 10.17219/acem/75511

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.