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[Determination of the naturally occurring Q80K mutation in the HCV NS3 protease gene].

Klinicka mikrobiologie a infekcni lekarstvi - 1 Dec 2015

Kutová Radka, Plíšková Lenka, Štěpánová Vlasta, Plíšek Stanislav, Machač Jan

Abstract excerpt

OBJECTIVES: The aim was to introduce a diagnostic method for detecting variants of hepatitis C virus (HCV) with protease NS3 resistance primarily to simeprevir (Q80K mutation in HCV genotype 1a) and its subsequent use in routine practice. MATERIAL AND METHODS: The detection of HCV resistance-associated variants in the NS3 protease gene by sequence analysis was introduced in the molecular biology laboratory of...

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PMID: 26886497

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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