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Article

The potential impact of P53 and APO-1 genetic polymorphisms on hepatitis C genotype 4a susceptibility.

Gene - 15 Oct 2014

Eskander Emad F, Abd-Rabou Ahmed A, Mohamed Mervat S, Yahya Shaymaa M M, El Sherbini Ashraf, Shaker Olfat G

Abstract excerpt

The hepatitis C virus (HCV), the main cause of morbidity and mortality, is endemic worldwide. HCV causes cirrhosis and other complications that often lead to death. HCV is most common in underdeveloped nations, with the highest prevalence rates in Egypt. Tumor suppressor gene (P53) induces the expression of apoptotic antigen-1 gene (APO-1) by binding to its promoter for mediating apoptosis; an important mechanism...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25108128
DOI: 10.1016/j.gene.2014.08.011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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