Article
Influence of amino acid variations in the NS3, NS4A and NS4B of HCV genotypes 1a, 1b, 3a, 3b and 6f on the response to pegylated interferon and ribavirin combination therapy.
Virus research - 22 Jan 2015
Chusri Pattranuch, Kumthip Kattareeya, Pantip Chansom, Thongsawat Satawat, O'Brien Amornrat, Maneekarn Niwat
Abstract excerpt
BACKGROUND: It has been suggested that HCV proteins, core, NS3/4A, NS4B, and NS5A, contribute to the resistance of HCV to IFN and ribavirin (RBV) treatments. AIM: To assess the effects of HCV amino acid variations in NS3, NS4A and NS4B of HCV subtypes 1a, 1b, 3a, 3b and 6f on the response to pegylated interferon (Peg-IFN) and RBV therapy. METHODS: One hundred and thirty four HCV isolates of genotypes 1a, 1b, 3a,...
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