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Article

BLM Potentiates c-Jun Degradation and Alters Its Function as an Oncogenic Transcription Factor.

Cell reports - 24 Jul 2018

Priyadarshini Raina, Hussain Mansoor, Attri Preeti, Kaur Ekjot, Tripathi Vivek, Priya Swati, Dhapola Parashar, Saha Dhurjhoti, Madhavan Vinoth, Chowdhury Shantanu, Sengupta Sagar

Abstract excerpt

Mutations in BLM helicase predispose Bloom syndrome (BS) patients to a wide spectrum of cancers. We demonstrate that MIB1-ubiquitylated BLM in G1 phase functions as an adaptor protein by enhancing the binding of transcription factor c-Jun and its E3 ligase, Fbw7α. BLM enhances the K48/K63-linked ubiquitylation on c-Jun, thereby enhancing the rate of its subsequent degradation. Functionally defective Fbw7α mutants...

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Source

Identifiers

PMID: 30044990
DOI: 10.1016/j.celrep.2018.06.101

Genes

BLM
MIB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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