Article
Genetic variation of the transcription factor GATA3, not STAT4, is associated with the risk of type 2 diabetes in the Bangladeshi population.
PloS one - 1 Jan 2018
Huda Nafiul, Hosen Md Ismail, Yasmin Tahirah, Sarkar Pankaj Kumar, Hasan A K M Mahbub, Nabi A H M Nurun
Abstract excerpt
Type 2 diabetes mellitus is a multifactorial metabolic disorder caused by environmental factors and has a strong association with hereditary issues. These hereditary issues result in an imbalance in CD4+T cells and a decreased level of naïve CD4+T cells, which may be critical in the pathogenesis of type 2 diabetes. Transcription factors GATA3 and STAT4 mediate the cytokine-induced development of naïve T cells...
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