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Article

Identification and functional study of GATA4 gene regulatory variants in type 2 diabetes mellitus.

BMC endocrine disorders - 17 Apr 2021

Ding Liangcai, Cai Mengdi, Chen Lu, Yan Han, Lu Shicheng, Pang Shuchao, Yan Bo

Abstract excerpt

BACKGROUND: Type 2 diabetes mellitus (T2D) is a common and complex disease. Dysfunction of pancreatic β cells, which cannot release sufficient insulin, plays a central role in T2D. Genetics plays a critical role in T2D etiology. Transcription factor GATA4 is required for the pancreatic development, and GATA4 gene mutations are implicated in neonatal or childhood-onset diabetes. In this study, we aimed to...

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Identifiers

PMID: 33865372
DOI: 10.1186/s12902-021-00739-0
PMCID: PMC8052808

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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