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Article

Key Genes And Pathways Controlled By E2F1 In Human Castration-Resistant Prostate Cancer Cells

1 Oct 2019

Abstract excerpt

Background: Treatment of castration-resistant prostate cancer (CRPC) is an enormous challenge. As E2F transcription factor 1 (E2F1) is an essential factor in CRPC, this study investigated the genes and pathways controlled by E2F1 and their effects on cellular behavior in CRPC. Methods: In vitro assays were used to evaluate cellular proliferation, apoptosis, and behavior. Cellular expression was quantified by RNA...

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PMID: 31802906
DOI: 10.2147/ott.s217347

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