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Article

HBV DNA Integration: Molecular Mechanisms and Clinical Implications

10 Apr 2017

Abstract excerpt

Chronic infection with the Hepatitis B Virus (HBV) is a major cause of liver-related morbidity and mortality. One peculiar observation in cells infected with HBV (or with closely‑related animal hepadnaviruses) is the presence of viral DNA integration in the host cell genome, despite this form being a replicative dead-end for the virus. The frequent finding of somatic integration of viral DNA suggests an...

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PMID: 28394272
DOI: 10.3390/v9040075

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