Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mediator complex subunit Med12 regulates cardiac jelly development and AV valve formation in zebrafish.

Progress in biophysics and molecular biology - 1 Oct 2018

Segert Julia, Schneider Isabelle, Berger Ina M, Rottbauer Wolfgang, Just Steffen

Abstract excerpt

The molecular mechanism essential for the formation of heart valves involves complex interactions of signaling molecules and transcription factors. The Mediator Complex (MC) functions as multi-subunit machinery to orchestrate gene transcription, especially for tissue-specific fine-tuning of transcriptional processes during development, also in the heart. Here, we analyzed the role of the MC subunit Med12 during...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Endocardium
Share to Gene Expression Regulation, Developmental

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Heart Valves

Share to Mediator Complex

Share to Mutation

Share to Zebrafish

Share to Zebrafish Proteins

Source

Identifiers

PMID: 30036562
DOI: 10.1016/j.pbiomolbio.2018.07.010

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mediator complex subunit Med12 regulates cardiac jelly development and AV valve formation in zebrafish.PMID 30036562Read ↗

The mediator complex subunit Med10 regulates heart valve formation in zebrafish by controlling Tbx2b-mediated Has2 expression and cardiac jelly formation.Semantic proximity Read ↗

Bmp2 is essential for cardiac cushion epithelial-mesenchymal transition and myocardial patterning.Semantic proximity Read ↗

SOX9 modulates the expression of key transcription factors required for heart valve developmentSemantic proximity Read ↗

Tbx2 and Tbx3 induce atrioventricular myocardial development and endocardial cushion formationSemantic proximity Read ↗

Sema6D acts downstream of bone morphogenetic protein signalling to promote atrioventricular cushion development in miceSemantic proximity Read ↗

Morphogenesis and molecular considerations on congenital cardiac septal defectsSemantic proximity Read ↗

Med12 is essential for early mouse development and for canonical Wnt and Wnt/PCP signaling.Semantic proximity Read ↗

Transmembrane protein 2 (Tmem2) is required to regionally restrict atrioventricular canal boundary and endocardial cushion development.Semantic proximity Read ↗

Bmp6 and Bmp7 are required for cushion formation and septation in the developing mouse heart.Semantic proximity Read ↗

Control of endocardial cushion and cardiac valve maturation by BMP signaling pathways.Semantic proximity Read ↗

Essential Role for ADAM19 in Cardiovascular MorphogenesisSemantic proximity Read ↗

Essential role of Sox9 in the pathway that controls formation of cardiac valves and septa.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.