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Article

Med12 is essential for early mouse development and for canonical Wnt and Wnt/PCP signaling.

Development (Cambridge, England) - 1 Aug 2010

Rocha Pedro P, Scholze Manuela, Bleiss Wilfrid, Schrewe Heinrich

Abstract excerpt

The Mediator complex is commonly seen as a molecular bridge that connects DNA-bound transcription factors to the RNA polymerase II (Pol II) machinery. It is a large complex of 30 subunits that is present in all eukaryotes. The Med12 subunit has been implicated not only in the regulation of Pol II activity, but also in the binding of transcription factors to the bulk of the Mediator complex. We targeted Med12 in...

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Identifiers

PMID: 20630950
DOI: 10.1242/dev.053660

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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