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Article

Altered N-methyl D-aspartate receptor subunit expression causes changes to the circadian clock and cell phenotype in osteoarthritic chondrocytes.

Osteoarthritis and cartilage - 1 Nov 2018

Kalev-Zylinska M L, Hearn J I, Rong J, Zhu M, Munro J, Cornish J, Dalbeth N, Poulsen R C

Abstract excerpt

The chondrocyte circadian clock is altered in osteoarthritis. This change is implicated in the disease-associated changes in chondrocyte phenotype and cartilage loss. Why the clock is changed is unknown. N-methyl-D-aspartate receptors (NMDAR) are critical for regulating the hypothalamic clock. Chondrocytes also express NMDAR and the type of NMDAR subunits expressed changes in osteoarthritis. OBJECTIVE: To...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptors, N-Methyl-D-Aspartate

Source

Identifiers

PMID: 30031924
DOI: 10.1016/j.joca.2018.06.015

Genes

PER2
BMAL1
MMP13
SOX9
RUNX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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