Back to search

Article

Circadian rhythm protein Bmal1 modulates cartilage gene expression in temporomandibular joint osteoarthritis via the MAPK/ERK pathway

2020-04-20

Abstract excerpt

<title>Abstract</title> <p><bold>Background: </bold>The purpose of this study was to elucidate the role of the circadian gene Bmal1 in human cartilage and its crosstalk with the MAPK/ERK signaling pathway in temporomandibular joint osteoarthritis (TMJ-OA).<bold>Methods: </bold>We verified the periodical variation of the circadian gene Bmal1 and then established a modified multiple platform method (MMPM) to induce...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
be7f33e7-b9ff-5726-879b-e43d0debcf17
DOI
10.21203/rs.3.rs-22124/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Circadian rhythm protein Bmal1 modulates cartilage gene expression in temporomandibular joint osteoarthritis via the MAPK/ERK pathwayDOI 10.21203/rs.3.rs-22124/v1
Clock gene Bmal1 influences the cell cycle of chondrocytes in osteoarthritisSemantic proximity
The chondrocyte clock gene Bmal1 controls cartilage homeostasis and integritySemantic proximity
Deletion of clock gene Bmal1 impaired the chondrocyte function due to disruption of the HIF1α-VEGF signaling pathwaySemantic proximity
The Circadian Clock in Murine Chondrocytes Regulates Genes Controlling Key Aspects of Cartilage HomeostasisSemantic proximity
Tick tock, the cartilage clockSemantic proximity
Clock Gene Bmal1 Modulates Human Cartilage Gene Expression by Crosstalk With Sirt1Semantic proximity
Comprehensive Analysis Reveals the Potential Diagnostic Value of Biomarkers Associated With Aging and Circadian Rhythm in Knee OsteoarthritisSemantic proximity
The circadian clock gene Bmal1: Role in COVID-19 and periodontitisSemantic proximity
BMAL1-TTK-H2Bub1 loop deficiency contributes to impaired BM-MSC-mediated bone formation in senile osteoporosisSemantic proximity
The circadian regulator PER1 inhibits osteoclastogenesis by activating inflammatory genesSemantic proximity
The clock transcription factor BMAL1 is a key regulator of extracellular matrix homeostasis and cell fate in the intervertebral discSemantic proximity
The clock transcription factor BMAL1 is a key regulator of extracellular matrix homeostasis and cell fate in the intervertebral discSemantic proximity
Select a neighboring publication to make it the new centre.