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Article

Clock Gene Bmal1 Modulates Human Cartilage Gene Expression by Crosstalk With Sirt1

1 Jun 2016

Abstract excerpt

The critical regulation of the peripheral circadian gene implicated in osteoarthritis (OA) has been recently recognized; however, the causative role and clinical potential of the peripheral circadian rhythm attributable to such effects remain elusive. The purpose of this study was to elucidate the role of a circadian gene Bmal1 in human cartilage and pathophysiology of osteoarthritis. In our present study, the...

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PMID: 27253997
DOI: 10.1210/en.2015-2042

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