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Article

Differential requirements for IKKalpha and IKKbeta in the differentiation of primary human osteoarthritic chondrocytes.

Arthritis and rheumatism - 1 Jan 2008

Olivotto Eleonora, Borzi Rosa Maria, Vitellozzi Roberta, Pagani Stefania, Facchini Annalisa, Battistelli Michela, Penzo Marianna, Li Xiang, Flamigni Flavio, Li Jun, Falcieri Elisabetta, Facchini Andrea, Marcu Kenneth B

Abstract excerpt

OBJECTIVE: Osteoarthritic (OA) chondrocytes behave in an intrinsically deregulated manner, characterized by chronic loss of healthy cartilage and inappropriate differentiation to a hypertrophic-like state. IKKalpha and IKKbeta are essential kinases that activate NF-kappaB transcription factors, which in turn regulate cell differentiation and inflammation. This study was undertaken to investigate the differential...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18163512
DOI: 10.1002/art.23211
PMCID: PMC2927097

Genes

SOX9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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