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Article

Generation and Validation of a Complete Knockout Model of abcc6a in Zebrafish.

The Journal of investigative dermatology - 1 Nov 2018

Van Gils M, Willaert A, De Vilder E Y G, Coucke P J, Vanakker O M

Abstract excerpt

Pseudoxanthoma elasticum is an ectopic mineralization disease due to biallelic ABCC6 mutations. As no treatment options are currently available, a reliable zebrafish model is invaluable for high throughput compound screening. However, data from previously reported knockdown and mutant zebrafish models for abcc6a, the functional orthologue of ABCC6, showed phenotypic discrepancies. To address this, we developed a...

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Source

Identifiers

PMID: 30030150
DOI: 10.1016/j.jid.2018.06.183

Genes

ABCC6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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