Article
Vitamin K reduces hypermineralisation in zebrafish models of PXE and GACI.
Development (Cambridge, England) - 15 Mar 2015
Mackay Eirinn W, Apschner Alexander, Schulte-Merker Stefan
Abstract excerpt
The mineralisation disorder pseudoxanthoma elasticum (PXE) is associated with mutations in the transporter protein ABCC6. Patients with PXE suffer from calcified lesions in the skin, eyes and vasculature, and PXE is related to a more severe vascular calcification syndrome called generalised arterial calcification of infancy (GACI). Mutations in ABCC6 are linked to reduced levels of circulating vitamin K. Here, we...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.