Article
Integrative genomics in combination with RNA interference identifies prognostic and functionally relevant gene targets for oral squamous cell carcinoma.
PLoS genetics - 1 Jan 2013
Xu Chang, Wang Pei, Liu Yan, Zhang Yuzheng, Fan Wenhong, Upton Melissa P, Lohavanichbutr Pawadee, Houck John R, Doody David R, Futran Neal D, Zhao Lue Ping, Schwartz Stephen M, Chen Chu, Méndez Eduardo
Abstract excerpt
In oral squamous cell carcinoma (OSCC), metastasis to lymph nodes is associated with a 50% reduction in 5-year survival. To identify a metastatic gene set based on DNA copy number abnormalities (CNAs) of differentially expressed genes, we compared DNA and RNA of OSCC cells laser-microdissected from non-metastatic primary tumors (n = 17) with those from lymph node metastases (n = 20), using Affymetrix 250K Nsp...
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