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Article

Reversal of Aging-Induced Increases in Aortic Stiffness by Targeting Cytoskeletal Protein-Protein Interfaces.

Journal of the American Heart Association - 18 Jul 2018

Nicholson Christopher J, Singh Kuldeep, Saphirstein Robert J, Gao Yuan Z, Li Qian, Chiu Joanna G, Leavis Paul, Verwoert Germaine C, Mitchell G F, Porter Tyrone, Morgan Kathleen G

Abstract excerpt

BACKGROUND: The proximal aorta normally functions as a critical shock absorber that protects small downstream vessels from damage by pressure and flow pulsatility generated by the heart during systole. This shock absorber function is impaired with age because of aortic stiffening. METHODS AND RESULTS: We examined the contribution of common genetic variation to aortic stiffness in humans by interrogating results...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Muscle, Smooth, Vascular

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Source

Open in PubMed Open full text

Identifiers

PMID: 30021807
DOI: 10.1161/JAHA.118.008926
PMCID: PMC6201469

Genes

VASP
WASL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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