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Article

Shortening of the elastic tandem immunoglobulin segment of titin leads to diastolic dysfunction.

Circulation - 2 Jul 2013

Chung Charles S, Hutchinson Kirk R, Methawasin Mei, Saripalli Chandra, Smith John E, Hidalgo Carlos G, Luo Xiuju, Labeit Siegfried, Guo Caiying, Granzier Henk L

Abstract excerpt

BACKGROUND: Diastolic dysfunction is a poorly understood but clinically pervasive syndrome that is characterized by increased diastolic stiffness. Titin is the main determinant of cellular passive stiffness. However, the physiological role that the tandem immunoglobulin (Ig) segment of titin play...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23709671
DOI: 10.1161/CIRCULATIONAHA.112.001268
PMCID: PMC3822017

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23709671-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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