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Article

Shortening of the elastic tandem immunoglobulin segment of titin leads to diastolic dysfunction.

Circulation - 2 Jul 2013

Chung Charles S, Hutchinson Kirk R, Methawasin Mei, Saripalli Chandra, Smith John E, Hidalgo Carlos G, Luo Xiuju, Labeit Siegfried, Guo Caiying, Granzier Henk L

Abstract excerpt

BACKGROUND: Diastolic dysfunction is a poorly understood but clinically pervasive syndrome that is characterized by increased diastolic stiffness. Titin is the main determinant of cellular passive stiffness. However, the physiological role that the tandem immunoglobulin (Ig) segment of titin plays in stiffness generation and whether shortening this segment is sufficient to cause diastolic dysfunction need to be...

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Identifiers

PMID: 23709671
DOI: 10.1161/CIRCULATIONAHA.112.001268
PMCID: PMC3822017

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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