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Article

Mutation of the 5'-untranslated region stem-loop mRNA structure reduces type I collagen deposition and arterial stiffness in male obese mice.

American journal of physiology. Heart and circulatory physiology - 1 Aug 2021

Ramirez-Perez Francisco I, Woodford Makenzie L, Morales-Quinones Mariana, Grunewald Zachary I, Cabral-Amador Francisco J, Yoshida Tadashi, Brenner David A, Manrique-Acevedo Camila, Martinez-Lemus Luis A, Chandrasekar Bysani, Padilla Jaume

Abstract excerpt

Arterial stiffening, a characteristic feature of obesity and type 2 diabetes, contributes to the development and progression of cardiovascular diseases (CVD). Currently, no effective prophylaxis or therapeutics is available to prevent or treat arterial stiffening. A better understanding of the molecular mechanisms underlying arterial stiffening is vital to identify newer targets and strategies to reduce CVD...

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Identifiers

PMID: 34242094
DOI: 10.1152/ajpheart.00076.2021
PMCID: PMC8526337

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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