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Metabolic phenotypes in a Lyz2Cre recombinase mouse model

18 Mar 2025

Abstract excerpt

The Cre-Lox system is essential in biomedical research for precise gene deletion in specific cell types, crucial for understanding genetic roles in disease. Although generally considered non-detrimental, Cre recombinase expression has been associated with potential adverse effects, including Cre toxicity, ectopic expression, and disruption of endogenous genes. We investigated the role of macrophage...

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PMID: 40170862
DOI: 10.3389/fimmu.2025.1499858

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