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Unexpected Genomic and Phenotypic Diversity of Mycobacterium africanum Lineage 5 Affects Drug Resistance, Protein Secretion, and Immunogenicity.

Genome biology and evolution - 1 Aug 2018

Ates Louis S, Dippenaar Anzaan, Sayes Fadel, Pawlik Alexandre, Bouchier Christiane, Ma Laurence, Warren Robin M, Sougakoff Wladimir, Majlessi Laleh, van Heijst Jeroen W J, Brossier Florence, Brosch Roland

Abstract excerpt

Mycobacterium africanum consists of Lineages L5 and L6 of the Mycobacterium tuberculosis complex (MTBC) and causes human tuberculosis in specific regions of Western Africa, but is generally not transmitted in other parts of the world. Since M. africanum is evolutionarily closely placed between the globally dispersed Mycobacterium tuberculosis and animal-adapted MTBC-members, these lineages provide valuable...

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PMID: 30010947
DOI: 10.1093/gbe/evy145
PMCID: PMC6071665

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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