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Article

Phenotypic instability of chondrocytes in osteoarthritis: on a path to hypertrophy.

Annals of the New York Academy of Sciences - 1 Apr 2019

Singh Purva, Marcu Kenneth B, Goldring Mary B, Otero Miguel

Abstract excerpt

Articular chondrocytes are quiescent, fully differentiated cells responsible for the homeostasis of adult articular cartilage by maintaining cellular survival functions and the fine-tuned balance between anabolic and catabolic functions. This balance requires phenotypic stability that is lost in osteoarthritis (OA), a disease that affects and involves all joint tissues and especially impacts articular cartilage...

Topics

Animals
Cell Proliferation
Chondrocytes
Epigenesis, Genetic
Humans
Hypertrophy
Osteoarthritis
Phenotype
Transcription, Genetic

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 30008181
DOI: 10.1111/nyas.13930

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