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Article

Six Germline Genetic Variations Impair the Translesion Synthesis Activity of Human DNA Polymerase κ.

Chemical research in toxicology - 17 Oct 2016

Kim Jae-Kwon, Yeom Mina, Hong Jin-Kyung, Song Insil, Lee Young-Sam, Guengerich F Peter, Choi Jeong-Yun

Abstract excerpt

DNA polymerase (pol) κ efficiently catalyzes error-free translesion DNA synthesis (TLS) opposite bulky N2-guanyl lesions induced by carcinogens such as polycyclic aromatic hydrocarbons. We investigated the biochemical effects of nine human nonsynonymous germline POLK variations on the TLS properties of pol κ, utilizing recombinant pol κ (residues 1-526) enzymes and DNA templates containing an...

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Identifiers

PMID: 27603496
DOI: 10.1021/acs.chemrestox.6b00244
PMCID: PMC5116392

Genes

POLK

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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