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Article

TROP2 methylation and expression in tamoxifen-resistant breast cancer

5 Jul 2018

Abstract excerpt

The DNA methyltransferase 1 inhibitor, 5-Aza-2′-deoxycytidine (5-Aza-dC) is a potential treatment for breast cancer. However, not all breast tumors will respond similarly to treatment with 5-Aza-dC, and little is known regarding the response of hormone-resistant breast cancers to 5-Aza-dC. We demonstrate that 5-Aza-dC-treatment has a stronger effect on an estrogen receptor-negative, Tamoxifen-selected cell line,...

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PMID: 30002602
DOI: 10.1186/s12935-018-0589-9

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