Article

Epigenetic Modulation of SPCA2 Reverses Epithelial to Mesenchymal Transition in Breast Cancer Cells

2020-11-12

Abstract excerpt

The secretory pathway Ca 2+ -ATPase SPCA2 is a tumor suppressor in triple receptor negative breast cancer (TNBC), a highly aggressive molecular subtype that lacks tailored treatment options. Low expression of SPCA2 in TNBC confers poor survival prognosis in patients. Previous work has established that re-introducing SPCA2 to TNBC cells restores basal Ca 2+ signaling, represses mesenchymal gene expression, mitiga...

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Literature Corpus work: 34166bca-cdb2-58d4-9f8f-3f35c8b37c60
DOI: 10.1101/2020.11.12.379685

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