Article
A novel Atg5-shRNA mouse model enables temporal control of Autophagy in vivo.
Autophagy - 1 Jan 2018
Cassidy Liam D, Young Andrew Rj, Pérez-Mancera Pedro A, Nimmervoll Birgit, Jaulim Adil, Chen Hung-Chang, McIntyre Dominick J O, Brais Rebecca, Ricketts Thomas, Pacey Simon, De La Roche Maike, Gilbertson Richard J, Rubinsztein David C, Narita Masashi
Abstract excerpt
Macroautophagy/autophagy is an evolutionarily conserved catabolic pathway whose modulation has been linked to diverse disease states, including age-associated disorders. Conventional and conditional whole-body knockout mouse models of key autophagy genes display perinatal death and lethal neurotoxicity, respectively, limiting their applications for in vivo studies. Here, we have developed an inducible shRNA mouse...
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