Article
Temporal inhibition of autophagy reveals segmental reversal of ageing with increased cancer risk.
Nature communications - 16 Jan 2020
Cassidy Liam D, Young Andrew R J, Young Christopher N J, Soilleux Elizabeth J, Fielder Edward, Weigand Bettina M, Lagnado Anthony, Brais Rebecca, Ktistakis Nicholas T, Wiggins Kimberley A, Pyrillou Katerina, Clarke Murray C H, Jurk Diana, Passos Joao F, Narita Masashi
Abstract excerpt
Autophagy is an important cellular degradation pathway with a central role in metabolism as well as basic quality control, two processes inextricably linked to ageing. A decrease in autophagy is associated with increasing age, yet it is unknown if this is causal in the ageing process, and whether autophagy restoration can counteract these ageing effects. Here we demonstrate that systemic autophagy inhibition...
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