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Article

Macroautophagy deficiency mediates age-dependent neurodegeneration through a phospho-tau pathway

21 Sept 2012

Abstract excerpt

BACKGROUND: Macroautophagy is an evolutionarily conserved mechanism for bulk intracellular degradation of proteins and organelles. Pathological studies have implicated macroautophagy defects in human neurodegenerative disorders of aging including Alzheimer's disease and tauopathies. Neuronal deficiency of macroautophagy throughout mouse embryonic development results in neurodevelopmental defects and early...

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PMID: 22998728
DOI: 10.1186/1750-1326-7-48

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