Combined loss of ATG4B, ATG4C and ATG4D impairs systemic autophagy and triggers accelerated aging in mice

Abstract excerpt

<h4>ABSTRACT</h4> Autophagy is an essential catabolic pathway that safeguards cellular and tissue homeostasis, yet the systemic consequences of its impairment in mammals remain poorly defined because complete autophagy ablation is embryonic or perinatal lethal. Here, we generate ATG4A-only mice, a model in which ATG4A is the sole remaining ATG4 protease due to combined ATG4B/C/D deletion. Through comprehensive bi...

Topics

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• Adenosine and Purinergic Signaling
• Autophagy in Disease and Therapy
• Cannabis and Cannabinoid Research
• Endoplasmic Reticulum Stress and Disease
• Genetics, Aging, and Longevity in Model Organisms
• Neuroinflammation and Neurodegeneration Mechanisms
• Polyamine Metabolism and Applications
• Sirtuins and Resveratrol in Medicine

Identifiers and source

Literature Corpus work

2c16aa2f-2048-58d4-96f4-e7ef170e8299

DOI

10.1101/2025.01.25.634746