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Article

Counterregulatory responses to hypoglycemia in patients with maturity-onset diabetes of the young caused by HNF-1alpha gene mutations (MODY3).

European journal of endocrinology - 1 Jan 2001

Guenat E, Seematter G, Philippe J, Temler E, Jéquier E, Tappy L

Abstract excerpt

Mutations of HNF-1alpha lead to severe beta cell dysfunction, resulting in decreased glucose-induced insulin secretion. HNF-1alpha is also expressed in liver, kidney and pancreatic alpha cells, but the functional consequences of HNF-1alpha mutations in these organs remain unknown. We therefore assessed the counterregulatory responses to hypoglycemia in six patients with HNF-1alpha mutations (MODY3), five patients...

Topics

Blood Glucose
DNA-Binding Proteins
Diabetes Mellitus, Type 2
Female
Glucagon
Glucose
Glucose Clamp Technique
Hepatocyte Nuclear Factor 1
Hepatocyte Nuclear Factor 1-alpha
Hepatocyte Nuclear Factor 1-beta

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Homeostasis

Humans

Hypoglycemia

Insulin

Male

Mutation

Nuclear Proteins

Transcription Factors

Source

Identifiers

PMID: 11174836
DOI: 10.1530/eje.0.1440045

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Counterregulatory responses to hypoglycemia in patients with maturity-onset diabetes of the young caused by HNF-1alpha gene mutations (MODY3).PMID 11174836Read ↗

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