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Article

A TFEB nuclear export signal integrates amino acid supply and glucose availability.

Nature communications - 11 Jul 2018

Li Linxin, Friedrichsen Hans J, Andrews Sarah, Picaud Sarah, Volpon Laurent, Ngeow Kaochin, Berridge Georgina, Fischer Roman, Borden Katherine L B, Filippakopoulos Panagis, Goding Colin R

Abstract excerpt

How cells coordinate the response to fluctuating carbon and nitrogen availability required to maintain effective homeostasis is a key issue. Amino acid limitation that inactivates mTORC1 promotes de-phosphorylation and nuclear translocation of Transcription Factor EB (TFEB), a key transcriptional regulator of lysosome biogenesis and autophagy that is deregulated in cancer and neurodegeneration. Beyond its...

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Share to Basic Helix-Loop-Helix Leucine Zipper Transcription Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29992949
DOI: 10.1038/s41467-018-04849-7
PMCID: PMC6041281

Genes

TFEB
NES

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

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A TFEB nuclear export signal integrates amino acid supply and glucose availability.PMID 29992949Read ↗

The transcription factor TFEB links mTORC1 signaling to transcriptional control of lysosome homeostasis.Semantic proximity Read ↗

TFEB; Beyond Its Role as an Autophagy and Lysosomes RegulatorSemantic proximity Read ↗

From the regulatory mechanism of TFEB to its therapeutic implicationsSemantic proximity Read ↗

TFEB acetylation promotes lysosome biogenesis and ameliorates Alzheimer's disease-relevant phenotypes in mice.Semantic proximity Read ↗

The Role and Regulatory Mechanism of Transcription Factor EB in Health and DiseasesSemantic proximity Read ↗

Glucosylation by the Legionella Effector SetA Promotes the Nuclear Localization of the Transcription Factor TFEBSemantic proximity Read ↗

Transcription factor EB: from master coordinator of lysosomal pathways to candidate therapeutic target in degenerative storage diseasesSemantic proximity Read ↗

TFEB degradation is regulated by an IKK/β-TrCP2 phosphorylation-ubiquitination cascadeSemantic proximity Read ↗

TFEB-driven endocytosis coordinates MTORC1 signaling and autophagySemantic proximity Read ↗

Requirement of FLCN tumor suppressor gene for mTORC1-mediated inhibition of TFE3 transcriptional activitySemantic proximity Read ↗

TFEB Signalling-Related MicroRNAs and AutophagySemantic proximity Read ↗

TFEB and TFE3 have cell-type specific expression in the brain and divergent roles in neuronsSemantic proximity Read ↗

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