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Article

Cyclin D1 overexpression induces global transcriptional downregulation in lymphoid neoplasms

10 Jul 2018

Abstract excerpt

Cyclin D1 is an oncogene frequently overexpressed in human cancers that has a dual function as cell cycle and transcriptional regulator, although the latter is widely unexplored. Here, we investigated the transcriptional role of cyclin D1 in lymphoid tumor cells with cyclin D1 oncogenic overexpression. Cyclin D1 showed widespread binding to the promoters of most actively transcribed genes, and the promoter...

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PMID: 29990311
DOI: 10.1172/jci96520

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