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Article

Nuclear cyclin D1: An oncogenic driver in human cancer

4 May 2009

Abstract excerpt

Perturbations in the regulation of the core cell cycle machinery are frequently observed in human cancers. Cyclin D1 which functions as a mitogenic sensor and allosteric activator of CDK4/6, is one of the more frequently altered cell cycle regulators in cancers. Cyclin D1 is frequently overexpressed in cancers and its overexpression can be attributed to many factors including increased transcription, translation,...

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PMID: 19415697
DOI: 10.1002/jcp.21791

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