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Article

Three-dimensional cancer models mimic cell-matrix interactions in the tumour microenvironment

5 Jun 2014

Abstract excerpt

Basic in vitro systems can be used to model and assess complex diseases, such as cancer. Recent advances in this field include the incorporation of multiple cell types and extracellular matrix proteins into three-dimensional (3D) models to recapitulate the structure, organization and functionality of live tissue in situ. Cells within such a 3D environment behave very differently from cells on two-dimensional (2D)...

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PMID: 24903340
DOI: 10.1093/carcin/bgu108

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