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Article

Heterotypic signaling between dermal fibroblasts and melanoma cells induces phenotypic plasticity and proteome rearrangement in malignant cells.

Biochimica et biophysica acta. Proteins and proteomics - 1 Dec 2020

Pessotti Dayelle S, Andrade-Silva Débora, Serrano Solange M T, Zelanis André

Abstract excerpt

The signaling events triggered by soluble mediators released from both transformed and stromal cells shape the phenotype of tumoral cells and have significant implications in cancer development and progression. In this study we performed an in vitro heterotypic signaling assays by evaluating the proteome diversity of human dermal fibroblasts after stimulation with the conditioned media obtained from malignant...

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Identifiers

PMID: 32866629
DOI: 10.1016/j.bbapap.2020.140525

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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