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Article

Proteome-wide analysis reveals an age-associated cellular phenotype of in situ aged human fibroblasts.

Aging - 1 Oct 2014

Waldera-Lupa Daniel M, Kalfalah Faiza, Florea Ana-Maria, Sass Steffen, Kruse Fabian, Rieder Vera, Tigges Julia, Fritsche Ellen, Krutmann Jean, Busch Hauke, Boerries Melanie, Meyer Helmut E, Boege Fritz, Theis Fabian, Reifenberger Guido, Stühler Kai

Abstract excerpt

We analyzed an ex vivo model of in situ aged human dermal fibroblasts, obtained from 15 adult healthy donors from three different age groups using an unbiased quantitative proteome-wide approach applying label-free mass spectrometry. Thereby, we identified 2409 proteins, including 43 proteins with an age-associated abundance change. Most of the differentially abundant proteins have not been described in the...

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PMID: 25411231
DOI: 10.18632/aging.100698
PMCID: PMC4247387

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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