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Article

Recognition of conserved antigens by Th17 cells provides broad protection against pulmonary Haemophilus influenzae infection

9 Jul 2018

Abstract excerpt

(NTHi) is a major cause of community acquired pneumonia and exacerbation of chronic obstructive pulmonary disease. A current effort in NTHi vaccine development has focused on generating humoral responses and has been greatly impeded by antigenic variation among the numerous circulating NTHi strains. In this study, we showed that pulmonary immunization of mice with killed NTHi generated broad protection against...

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PMID: 29987031
DOI: 10.1073/pnas.1802261115

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